The main issue for God’s man and the Holy Spirit is control, and God wants to make that happen by filling us with His Holy Spirit. The word fill in the original language of the Bible means to “be influenced fully by” or to “be possessed fully by” an agent of control. So if I allow alcohol to influence me fully by drinking to excess, it will end up controlling my actions, which leads to ruin.
Contrast this to when God’s man yields total control to the influence of the Holy Spirit, which produces actions consistent with God’s plans.
Don’t act thoughtlessly, but try to understand what the Lord wants you to do. Don’t be drunk with wine,, because that will ruin your life. Instead, let the Holy Spirit fill and control you. Then you will sing psalms and hymns and spiritual songs among yourselves, making music to the Lord in your hearts. And you will always give thanks for everything to God the Father in the name of our Lord Jesus Christ. (EPHESIANS 5:17-20, NLT, emphasis added)